Antibiotics are naturally made by fungi and bacteria to compete for space and nutrients. Antibiotic resistance is a natural defense. Antibiotic resistance has become an issue because we have misused antibiotics and thus increased the exposure of bacteria to antibiotics. Medical use of antibiotics to kill pathogens is similar to being shot with your own stolen gun. Although we synthesize and purify antibiotics for human use, antibiotics originate in microbes. Life as a microbe is tough. Conditions in the soil are ever changing. Food and water are scarce. Microbes only move and reproduce if enough water and food are present. The rotting body of a housefly may seem trivial to humans. For microbes, it’s the biggest buffet in Vegas. It’s every microbe for herself and those with any trick up their pili or thallus to feed and divide faster to fill up the habitat space are the winners. Enter toxins that kill bacteria – antibiotics – literally meaning “against” “life”. Bacteria or fungi make and release these toxic substances into the environment to kill their competitors. The microbes making the toxins often protect themselves by targeting cell structures that they don’t have, but their competitors do. Similar to how Superman