Dear Beyoncé: May The Carter Twins Meet Helpful Microbial Life Partners

Dear Beyoncé: May The Carter Twins Meet Helpful Microbial Life Partners

An open letter to Beyoncé wishing her and her family well as the twins meet their microbial partners for life.  Dear Beyoncé, As you wait and prepare for the twins’ birth please don’t forget the invisible microbes that will protect, feed, and teach your babies for the rest of their lives.  Yep, I’m talking about “germs” or more politically correctly – “microbes”. Babies are “microbe magnets”. Those first microbes that baby encounters become their microbes for life. They are stuck together – life partners in sickness and in health. What’s cool is that these microbes are security guards keeping away diseases, chefs chopping up food to feed baby, and soothing Jedi masters who teach baby’s immune system what to kill and what to ignore. In my grandmother’s day, people in developed countries died from communicable diseases – polio, mumps, measles, yellow fever. Diseases that are spread from person to person by sneezing, coughing, or spread by insects, like mosquitos. Today people die from non-communicable diseases – diabetes, allergies, asthma, autoimmune diseases, and more. Our diseases today aren’t due to specific microbial pathogens. Vaccines, handwashing, clean water, sewers, and antibiotics keep these easy-to-spread microbial diseases at low numbers. Instead, today’s diseases

It’s All About the Breast Milk Sugars, Baby

It’s All About the Breast Milk Sugars, Baby

Helpful infant gut bacterium, Bifidobacterium infantis, uses special breast milk sugars to grow that other bacteria can’t use. Breast Milk Sugars Don’t Feed the Infant As parents we often try to limit sugar for our kids. However, with breast milk – the sugars are essential food for helpful bacteria that grow in an infant’s gut. Along with fats, water, antioxidants from mom’s diet, antibodies, and other compounds, breast milk has a diversity of complex carbohydrate sugars. Called human milk oligosaccharides (HMO), these chains of carbohydrates bonded together are difficult to break apart. Humans do not make the enzymes that can break these breast milk sugar bonds [1, 2]. Our helpful gut bacteria do [3-6]. Infants and most gut bacteria don’t have the enzymes in their guts to digest the sugars that dominate human breast milk. The beneficial bacterium, Bifidobacterium infantis, uses enzyme Endo BI-1 for breaking sugars to use for food. This may explain why B. infantis dominates the gut of breast fed babies. HMO sugars are extremely different from their refined and over-processed cousins that we use to sweeten our drinks and solid foods. Refined and processed sugars are primarily simple carbohydrates made of a few carbon molecules bound together

A Bacterial Scoop on Poop

A Bacterial Scoop on Poop

Changes in poop quantity, quality, and color is a concern to gut microbiome scientists and parents alike. In Science of Mom’s recent post “How Often Should a Baby Poop?” she discusses the amazing variability in pooping patterns between babies and also as a kid ages. I was, of course, excited to see that she mentioned a little about the influence of the gut microbiome, but her post inspired me to think more about pooping patterns from a microbiome perspective. Individual variability First, it’s not too surprising that there’s a huge variability between infants and pooping frequency. Several studies demonstrate that each individual’s gut microbiome is unique. In the guts of healthy adults, a single, unique bacterial strain can be used to identify each individual [1]. With each bacterial strain comes some unique abilities. Various bacterial taxa digest different foods and/or produce and transport different vitamins, amino acids, and other basic nutrients. So microbiome community A may process the nutrients faster, more efficiently, or completely than microbiome community B. That difference in the microbiome community function plus the differences in human gut anatomy due to human genetics could lead to a wide range in pooping frequency. Feeding differences Second, as Science