An open letter to Beyoncé wishing her and her family well as the twins meet their microbial partners for life. Dear Beyoncé, As you wait and prepare for the twins’ birth please don’t forget the invisible microbes that will protect, feed, and teach your babies for the rest of their lives. Yep, I’m talking about “germs” or more politically correctly – “microbes”. Babies are “microbe magnets”. Those first microbes that baby encounters become their microbes for life. They are stuck together – life partners in sickness and in health. What’s cool is that these microbes are security guards keeping away diseases, chefs chopping up food to feed baby, and soothing Jedi masters who teach baby’s immune system what to kill and what to ignore. In my grandmother’s day, people in developed countries died from communicable diseases – polio, mumps, measles, yellow fever. Diseases that are spread from person to person by sneezing, coughing, or spread by insects, like mosquitos. Today people die from non-communicable diseases – diabetes, allergies, asthma, autoimmune diseases, and more. Our diseases today aren’t due to specific microbial pathogens. Vaccines, handwashing, clean water, sewers, and antibiotics keep these easy-to-spread microbial diseases at low numbers. Instead, today’s diseases