PATHOGENESIS 2.0 and the “Sex”spansion

PATHOGENESIS 2.0 and the “Sex”spansion

It’s back and sexier than ever! My family’s favorite deck building game – Pathogenesis – expands to include an “adult” version as it launches a 2nd printing on Kickstarter February 12, 2019. No longer is your custom-created microbial army limited to attacking skin, gastrointestinal (GI), or respiratory (lung) systems. Instead, Pathogenesis gets sexy with specialized sexually transmitted disease (STD) microbes attacking the Genitourinary tract (GU). In turn, the human body comes to version 2.0 with a strengthened immune system that makes it harder than ever to beat. Which tract will you colonize? Will you succeed in penetrating the body’s barriers and dismantle the active immune system? Play and see. What is Pathogenesis? Pathogenesis is a deck-building game where you are tasked with creating a pathogen to *cue scary music * attack and destroy an organ system of the human body. In Pathogenesis everyone starts with the same number of starter cards (a mix of DNA cards and microbes). Each turn you can select a new trait (that enters your draw pile for future turns), add traits from your current hand to your pathogen pile, attack, and redraw. As you successfully attack the human body, you gain DNA points that can

Dear Beyoncé: May The Carter Twins Meet Helpful Microbial Life Partners

Dear Beyoncé: May The Carter Twins Meet Helpful Microbial Life Partners

An open letter to Beyoncé wishing her and her family well as the twins meet their microbial partners for life.  Dear Beyoncé, As you wait and prepare for the twins’ birth please don’t forget the invisible microbes that will protect, feed, and teach your babies for the rest of their lives.  Yep, I’m talking about “germs” or more politically correctly – “microbes”. Babies are “microbe magnets”. Those first microbes that baby encounters become their microbes for life. They are stuck together – life partners in sickness and in health. What’s cool is that these microbes are security guards keeping away diseases, chefs chopping up food to feed baby, and soothing Jedi masters who teach baby’s immune system what to kill and what to ignore. In my grandmother’s day, people in developed countries died from communicable diseases – polio, mumps, measles, yellow fever. Diseases that are spread from person to person by sneezing, coughing, or spread by insects, like mosquitos. Today people die from non-communicable diseases – diabetes, allergies, asthma, autoimmune diseases, and more. Our diseases today aren’t due to specific microbial pathogens. Vaccines, handwashing, clean water, sewers, and antibiotics keep these easy-to-spread microbial diseases at low numbers. Instead, today’s diseases

The Vaginal Microbiome During Pregnancy – At Least Something is Stable!

The Vaginal Microbiome During Pregnancy – At Least Something is Stable!

The vaginal microbiome during pregnancy is more stable than that of non-pregnant women. Women delivering at full-term gestation had a Lactobacillus dominant vaginal microbiome. Pregnancy is a human-body changer. Ask any woman who’s gone through it. My hair went from light blonde to this mousy blonde after my first trimester with my first baby, Jac. Never mind that baby belly I don’t think I’ll ever lose. That pooch is part of me now. Though I have to say, pregnancy was the one time in my life where my allergies and eczema weren’t a problem. So what about your microbial self? Your microbiome? Do all body sites have a more or less stable microbiome during pregnancy? Or do some body sites, like gut or vaginal microbiomes, change during pregnancy? Since birth seems to be the primary time that microbes are passed from mother to offspring, perhaps the vaginal microbiome would change as birth approaches. Vaginal Community State Types The Ravel lab sampled the vaginal fluid microbiome community throughout the pregnancy of 22 women who delivered babies at term [1]. The vaginal fluid microbiome of pregnant and non-pregnant women was compared. What the researchers found was that the vaginal bacterial communities of both pregnant and

Book Review:”Let Them Eat Dirt” – Save Your Child by Saving Their Microbes!

Book Review:”Let Them Eat Dirt” – Save Your Child by Saving Their Microbes!

  “Let Them Eat Dirt: Saving Your Child from an Oversanitized World” provides suggestions for a microbially rich and healthy childhood. Let Them Eat Dirt: Saving Your Child from an Oversanitized World talks directly to parents about the importance of microbes to your young kids. Authors  Brett Finlay, PhD and Marie-Claire Arrieta, PhD have an excellent message – let kids get dirty and quit abusing antibiotics. Let Them Eat Dirt is an engaging read clearly written and written clearly by scientist parents who have been in the “parenting trenches”. This microbiome parenting book is a fun read. Several times I laughed out loud at the references to pregnancy and parenting woes. As a scientist, I appreciated their overall message about the importance of microbes to our health.

“Seeding” a C-section Newborn with Vaginal Microbes: Can we? Should we?

“Seeding” a C-section Newborn with Vaginal Microbes: Can we? Should we?

New research is out today from the laboratory of Dr. Maria Gloria Dominguez-Bello demonstrating that at least part of mom’s vaginal microbiome can be transmitted to her c-section delivered infant. Infants born via c-section are at increased risk of developing non-communicable diseases such as asthma, diabetes, immune system disorders, and obesity. C-section babies frequently have a microbiome that is more similar to skin bacteria than mom’s vagina or GI tract. Swabbing a baby at birth with mom’s vaginal fluids is a potentially low cost, easy way to mimic one aspect of vaginal birth and transmit potentially beneficial microbes. Parents considering this procedure should check for the presence of pathogens such as Group B Strep and viral pathogens. Any such procedure should be discussed with your medical care team. For the full post – go to the post at Science and Sensibility’s website. Vaginal Seeding Procedure Illustration by Cara Gibson, Phd